XEOMIN®  is a prescription medicine, uniquely purified, used to temporarily reduce the appearance of moderate to severe frown lines that form between the eyebrows, around the outer area of eyes, and across the forehead in adults. Xeomin® works by blocking neural signals at the neuromuscular junction to prevent the targeted muscles from contracting. XEOMIN®  is manufactured by Merz Pharmaceuticals and was approved by the FDA to ease the appearance of frown lines in 2010. Xeomin® contains botulinum toxin type A, which is a uniquely purified protein from the bacterium Clostridium botulinum.  Due to its different form of botulinum toxin, it can be administered without any additive proteins. 

You may see smoothing occurring as early as 3-4 days after injection treatment. Maximum effects are noticed between 2-4 weeks, lasting up to 3 months.

Knowledge Card



Frown lines form when facial expressions are made as the muscle under the skin contracts. Over time, as your skin ages, these repeated expressions cause lasting frown lines. Neurotoxins, such as Xeomin®, are prescription medications that block the release of chemicals that cause these muscle contractions so frown lines are softened.


Xeomin® is made through a unique precision manufacturing process that isolates the therapeutic component of the molecule and removes the complexing/unnecessary proteins that don’t play an active role in treatment. Xeomin® is a uniquely purified neurotoxin. Studies have not been performed to determine whether the presence or absence of complexing/unnecessary proteins has a long-term effect on safety or efficacy.


XEOMIN is a prescription medicine:

  • that is injected into glands that make saliva and is used to treat long-lasting (chronic) drooling (sialorrhea) in adults and in children 2 to 17 years of age.
  • that is injected into muscles and used to:
    • treat increased muscle stiffness in the arm because of upper limb spasticity in adults.
    • treat increased muscle stiffness in the arm in children 2 to 17 years of age with upper limb spasticity, excluding spasticity caused by cerebral palsy.
    • treat the abnormal head position and neck pain with cervical dystonia (CD) in adults.
    • treat abnormal spasm of the eyelids (blepharospasm) in adults.

It is not known if XEOMIN is safe and effective in children younger than:

  • 2 years of age for the treatment of chronic sialorrhea
  • 2 years of age for the treatment of upper limb spasticity
  • 18 years of age for the treatment of cervical dystonia or blepharospasm


XEOMIN may cause serious side effects that can be life threatening. Get medical help right away if you have any of these problems any time (hours to weeks) after injection of XEOMIN:

  • Problems swallowing, speaking, or breathing can happen if the muscles that you use to breathe and swallow become weak. Death can happen as a complication if you have severe problems with swallowing or breathing after treatment with XEOMIN.
    • People with certain breathing problems may need to use muscles in their neck to help them breathe and may be at greater risk for serious breathing problems with XEOMIN.
    • Swallowing problems may last for several months, and during that time you may need a feeding tube to receive food and water. If swallowing problems are severe, food or liquids may go into your lungs. People who already have swallowing or breathing problems before receiving XEOMIN have the highest risk of getting these problems.
  • Spread of toxin effects. In some cases, the effect of botulinum toxin may affect areas of the body away from the injection site and cause symptoms of a serious condition called botulism. The symptoms of botulism include: loss of strength and muscle weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, trouble swallowing.

These symptoms can happen hours to weeks after you receive an injection of XEOMIN. These problems could make it unsafe for you to drive a car or do other dangerous activities.

Call Redefine By Z MediSpa today to schedule your complimentary skin care consultation and to learn more about our microneedling treatment today at 770-629-7989.